Perceptions of a Traditional High School Bell Schedule in the 21st Century

The daily bell schedule in a comprehensive high school has a significant impact on teaching and learning, school climate, and the well-being of students and staff. An increasing emphasis on the need for students to have strong critical thinking, problem solving, collaboration, and creativity skills provides an impetus for questioning the length of traditional class periods. This change leadership plan focuses on one school’s effort to examine their current school day schedule to determine what, if any, changes should be made to insure alignment between the daily bell schedule and the school’s mission and goals. Based on the work of a School Day Committee, a survey was developed to increase understanding of staff views about the current school day. Focusing on staff perceptions of how the current daily bell schedule impacts teaching and learning, student and staff well-being, and support for students, the survey results laid the groundwork for future work of the committee including a student survey

A Comparison of Cooperative Learning and Collaboration in High School Geometry Classes Including Geometry in Construction

Currently offered at over 450 high schools in the United States, Geometry in Construction is an interdisciplinary course that provides students with the opportunity to learn Geometry content through the process of constructing a single-family home. Highly functioning cooperative groups are a critical element of the Geometry in Construction program. Cooperative learning is an effective instructional strategy that increases student achievement (Slavin, 2011) and also provides opportunities for students to develop collaboration and teamwork skills. Collaboration and teamwork are critical 21st century skills that are highly valued by employers and therefore worthy of consideration as foundational skills to be taught and assessed in US schools. This program evaluation explores the use of cooperative learning in Geometry classrooms, including Geometry in Construction, and its relationship to students’ development of the 21st century skill of collaboration. This study involved observations in Geometry classes to document the use of the instructional strategy of cooperative learning as well as a review of data collected via a retrospective pretest of Geometry students’ attitudes toward math and perceptions of their 21st century skills. While the classroom observations did not reveal significant differences in the quantity or quality of small group work in Geometry in Construction versus other Geometry classes, the data collected via the observation process can lead to thoughtful discussion and planning to increase the use of cooperative learning strategies. The results of the retrospective pretest showed a higher percentage of all students in Geometry (Geometry in Construction and in all other Geometry classes combined) indicating that they believed statements related to teamwork and collaboration were often or almost always true for them at the end of the school year than what they believed to be true for themselves before they took their current Geometry class. However, the researcher was encouraged that for the majority of the statements related to teamwork and collaboration, the increase from pre to post was higher for Geometry in Construction students

Advocating for the Adoption of a Comprehensive Work-Based Learning System

Work-Based Learning (WBL) is an instructional strategy that has the potential to help students make powerful connections to the world of work leading to the development of viable post-secondary plans and successful careers. This study advocates for the implementation of a structured continuum of WBL experiences for all students at a large suburban high school. The benefits of WBL for students, the school, the community, and employers are examined. The impact of WBL is analyzed through the lenses of educational, economic, social, political, and ethical perspectives. The negative aspects of the prevailing culture of college for all is discussed. The importance of building and sustaining strong relationships between educators and the business community is highlighted, as well as the importance of addressing the effects of historic racism or bias in both education and employment. The author argues that with input from a range of stakeholders, high schools can develop, implement, and measure the success of comprehensive WBL systems leading to higher levels of post-secondary success for ALL graduates

MTHFR polymorphisms in relation to ovarian cancer risk

Objective Folate has been hypothesized to influence carcinogenesis due to its dual role in DNA methylation, which regulates gene expression, and synthesis of purine and thymidylate, which is vital for DNA repair. Thus, we examined ovarian cancer risk in relation to two functional polymorphisms (C677T and A1298C) in the MTHFR gene. Methods We genotyped the C677T (rs1801133) and A1298C (rs1801131) MTHFR polymorphisms in 1642 cases and 2068 controls from three studies, the New England Case Control Study (NEC), Nurses’ Health Study (NHS), and Mayo Clinic Ovarian Cancer Case Control Study (MAY). Results Overall, we observed no association between either SNP and ovarian cancer risk (pooled C677T ptrend = 0.59 and A1298C ptrend = 0.58). Significant associations (C677T ptrend=0.001, A1298C ptrend=0.02) between these MTHFR SNPs and serous ovarian cancer risk were observed in the NEC study, but were not replicated in the NHS and MAY studies. Conclusions MTHFR SNPs C677T and A1298C are not associated with ovarian cancer risk. Our results highlight the need for validation of genetic findings

Risk factors for ductal and lobular breast cancer: results from the nurses' health study

Introduction Ductal and lobular carcinomas are the two most common types of invasive breast cancer. Whether well-established risk factors are differentially associated with risk on the basis of histologic subtype is not clear. We prospectively investigated the association between a number of hormonal and nonhormonal exposures and risk defined by histologic subtype among 4,655 ductal and 659 lobular cases of postmenopausal breast cancer from the Nurses\u27 Health Study. Methods Multivariate Cox proportional hazards regression stratified by histologic subtype and time period was used to examine the association between risk factors and the incidence of ductal and lobular subtypes. For each exposure, we calculated the P value for heterogeneity using a likelihood ratio test comparing models with separate estimates for the two subtypes versus a single estimate across subtypes. Results The associations with age at menarche (P-heterogeneity (het) = 0.03), age at first birth (P-het \u3c 0.001) and postmenopausal hormone use (P-het \u3c 0.001) were more strongly associated with lobular cancers. The associations with age, nulliparity, parity, age at menopause, type of menopause, alcohol intake, adult body mass index (BMI), BMI at age 18, family history of breast cancer and personal history of benign breast disease did not vary by subtype (P-het ≥ 0.08). Results were similar when we restricted the analyses to estrogen receptor-positive and progesterone receptor-positive tumors. Conclusions These data indicate that breast cancer is a heterogeneous disease, and the differential association with a number of risk factors is suggestive of etiologically distinct tumors. Epidemiological analyses should continue to take into account a modifying role of histology

Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990 and TYMS rs495139 with risk of ovarian carcinoma overall, and to utilize the large sample of assembled cases to investigate associations by histological type

Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Background We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990 and TYMS rs495139 with risk of ovarian carcinoma overall, and to utilize the large sample of assembled cases to investigate associations by histological type. Methods Associations were evaluated in the Ovarian Cancer Association Consortium, including 16 studies of 5,593 epithelial ovarian carcinoma cases and 9,962 controls of white non-Hispanic origin. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age and study site. Results The five polymorphisms were not associated with ovarian carcinoma overall (P trend > 0.13); however, associations for the minor allele at TYMS rs495139 were observed for carcinomas of mucinous type (OR, 1.19; 95% CI, 1.03-1.39; P = 0.02), clear cell type (OR, 0.86; 95% CI, 0.75-0.99; P = 0.04) and endometrioid type (OR, 0.90; 95% CI, 0.81-0.99; P = 0.04) (P heterogeneity = 0.001). Restriction to low-grade mucinous carcinomas further strengthened the association for the mucinous type (OR, 1.32; 95% CI, 1.07-1.62; P = 0.01). TYMS rs495139 was not associated with serous type (OR, 1.06; 95% CI, 1.00-1.13; P = 0.05). Conclusions TYMS rs495139 may be associated with a differential risk of ovarian carcinoma types, indicating the importance of accurate histopathological classification. Impact Biomarkers that distinguish ovarian carcinoma types are few, and TYMS rs495139 may provide a novel clue to type etiology. Additional genotyping in a larger sample with increased gene coverage is underway

Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Background We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990 and TYMS rs495139 with risk of ovarian carcinoma overall, and to utilize the large sample of assembled cases to investigate associations by histological type. Methods Associations were evaluated in the Ovarian Cancer Association Consortium, including 16 studies of 5,593 epithelial ovarian carcinoma cases and 9,962 controls of white non-Hispanic origin. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age and study site. Results The five polymorphisms were not associated with ovarian carcinoma overall (P trend > 0.13); however, associations for the minor allele at TYMS rs495139 were observed for carcinomas of mucinous type (OR, 1.19; 95% CI, 1.03-1.39; P = 0.02), clear cell type (OR, 0.86; 95% CI, 0.75-0.99; P = 0.04) and endometrioid type (OR, 0.90; 95% CI, 0.81-0.99; P = 0.04) (P heterogeneity = 0.001). Restriction to low-grade mucinous carcinomas further strengthened the association for the mucinous type (OR, 1.32; 95% CI, 1.07-1.62; P = 0.01). TYMS rs495139 was not associated with serous type (OR, 1.06; 95% CI, 1.00-1.13; P = 0.05). Conclusions TYMS rs495139 may be associated with a differential risk of ovarian carcinoma types, indicating the importance of accurate histopathological classification. Impact Biomarkers that distinguish ovarian carcinoma types are few, and TYMS rs495139 may provide a novel clue to type etiology. Additional genotyping in a larger sample with increased gene coverage is underway

Marketing sport psychology consulting services

The field of applied sport psychology continues to increase in popularity and offers new and exciting career opportunities. In addition to offering consulting services to athletes, coaches, and teams, applied sport psychology professionals also serve military, dance, and business clients (Lloyd & Foster, 2006). This article outlines a 10-step process that sport psychology professionals can use to successfully market their consulting services, with examples for offering consulting services to athletes, coaches, and teams. This approach consists of a strategy and tactics integrating the traditional 4P\u27s approach to marketing (Pitts & Stotlar, 2007). As such, this article seeks to support the benefits of developing and implementing an integrated and comprehensive marketing plan to achieve optimal marketing success for a sport psychology practice. © Association for Applied Sport Psychology

Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk

Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-tagging single nucleotide polymorphisms in 1173 cases and 1201 controls from the New England Case–Control (NECC) study and 296 cases and 854 controls from the Nurses’ Health Study (NHS). The association of haplotypes and single nucleotide polymorphisms (SNPs) with ovarian cancer was estimated using unconditional (NECC) and conditional (NHS) logistic regression. Additionally, we evaluated the association of SNPs with IGF1, IGF-binding protein (IGFBP) 3 and IGFBP2 plasma levels (n = 380 NHS controls). Our data suggest a decreased risk for women carrying haplotype 2C of the IGF1 gene [odds ratios (ORs) = 0.82, 95% confidence intervals (CIs) = 0.69–0.98] and an increased risk for women carrying haplotype 1D (OR = 1.41, 95% CI = 1.03–1.94) or 2D (OR = 1.20, 95% CI = 1.01–1.41) in the binding proteins. When evaluated individually, three SNPs in the IGFBPs (rs10228265, rs4988515 and rs2270628) were associated with increased ovarian cancer risk, and several IGF1 (rs11111285, rs1996656 and rs1019731) and IGFBP3 (rs2270628, rs2854746 and rs2854744) SNPs were significantly associated with IGF1, IGFBP3 and IGFBP2 plasma levels. Some haplotypes and SNPs in the IGF pathway genes may be associated with ovarian cancer risk; however, these results need to be confirmed. Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk